DDI of the Month Podcast

The very latest updates on Drug-Drug Interactions hot off the presses!

Discover the Latest Episode

Available now on Spotify and Apple Podcasts 

Guest Speakers Episode 2 | Colchicine

Podcast Host

In the second episode of this podcast series, Dr Malone, Dr Gómez-Lumbreras, and Dr Burger will discuss the drug-drug interaction potential of colchicine, which may be underestimated. 

Dr. Malone’s research group did a study on real-world data on the interaction potential of colchicine. Colchicine concentration can be increased by CYP3A4 inhibitors, which may lead to toxicity and adverse events. Adverse events cases reported between 2004 and 2020 were studied for the involvement of colchicine in DDIs. In 66% of 787 studied reports, colchicine was identified as a concomitant drug.  This indicates that the reporter did not think colchicine was the cause of the adverse events mentioned in the reports. 

Could colchicine possibly play a bigger role in DDIs than currently thought? 
Are there any safety concerns of colchicine use combined with strong CYP3A4 inhibitors? 
And what practical guidance is needed for the safe use of colchicine in combination with other medicines?

Listen to the second episode of DDI of the Month to find out!

Guest Speaker Episode 1 | Flucloxacillin 

Podcast Host

In the first episode of this new podcast series, Dr Iversen and Dr Burger will dive into DDIs with flucloxacillin, and explore the results of Dr. Iversen's research trial.
 

Flucloxacillin is widely used to treat infections and is known to be an agonist of the nuclear receptor PXR. Combined with comedications, it may give an increased risk of drug-drug interactions and no guideline is available yet.

Dr. Iversen’s research group has studied the extent of induction of flucloxacillin of the CYP enzymes in healthy adults and 3D spheroid of primary human hepatocytes (PHHs). The research group performed a randomized, unblinded, two-period, cross-over, clinical pharmacokinetic (Basel) cocktail study with twelve healthy adults. During the podcast, the study will be discussed in detail.

Find out the interesting results of this study!

How do you avoid adverse drug interactions in this rapidly evolving field of pharmacological therapies?  

Presented by Global DDI Solutions in collaboration with Academic Medical Education, the DDI of the Month podcast brings you the latest updates on drug-drug interactions.

Each month, a new paper will be selected and the author invited to discuss their findings and explore how this can optimize DDI management and patient care going forward.

The podcast intended for everyone interested in DDI management or specific drugs, e.g. healthcare professionals, pharmacists, and researchers.

Go to the DDI Manager website to utilize the online resources designed to assist healthcare professionals in prescribing and enhancing overall quality of life for their patients.

You can access a DDI manager for a specific disease and search for the related drugs from there.