HIVPediatrics
Meeting category
Date(s)
16 Nov 2020 - 17 Nov 2020
EACCME Credits
6
Organizer
Platinum Level Support
Sponsor logos
ViiV Pediatrics

International Workshop on HIV Pediatrics 2020

Related Enduring Materials

Enduring Materials

Download the Program Book

Download the Abstracts Book

       

Day 1 - Monday, 16 November 2020

Session 1: Global Update -
The HIV Epidemic in Infants, Children, Adolescents and Women Today – 2020 UNAIDS Update
Mary Mahy, ScD, MHSc
UNAIDS, Switzerland
HIV and COVID-19, Double Trouble
Advances in Cure Research Across the Lifespan
Daniel Kuritzkes, MD
Brigham and Women's Hospital / Harvard Medical School, United States
Panel Discussion - Session 1: Global Update
Session 2: Oral Abstracts Presentations - Simultaneous -
Abstract Session 1: Pediatric HIV Treatment – Old drugs, New Drugs
Twenty-Four Week Safety, Tolerability and Efficacy of Dolutegravir Dispersible Tablets in Children 4 Weeks to <6 Years Old with HIV: Results from IMPAACT P1093
#1 Theodore Ruel, United States
Pediatric Dolutegravir (DTG) Dosing Recommendations Derived from Combined P1093 and ODYSSEY Population Pharmacokinetic Analysis
#2 Rajendra Singh, United States
Safety, Pharmacokinetics, and Efficacy of Low-Dose E/C/F/TAF in Virologically Suppressed Children ≥2 Years Old Living with HIV
#3 Eva Natukunda, United States
Safety, Pharmacokinetics And Acceptability Of The Abc/3tc/Lpv/R Granules (4-In-1) In Children Living With HIV (3-20kg) In Uganda: LOLIPOP Study
#4 Juliet Mwanga, Uganda
The “Dtgs” Of DTG for Children and Adolescents Living with HIV (CALHIV): Descriptions, Trends, and Gaps of Rolling Out Dolutegravir in CALHIV in Mbeya, Tanzania
#5 Jason Bacha, Tanzania
Acceptability of a New 4-In-1 Abacavir/Lamivudine/Lopinavir/Ritonavir Paediatric FixedDose Combination: The Caregiver-Child Dyads’ Perspective
#6 Ogara Collin
Discussion - Abstract Session 1: Pediatric HIV Treatment – Old drugs, New Drugs
Abstract Session 2: Diagnosis, Case-Finding, Retention and Viral Suppression in Children living with HV
A Validated Outpatient Department HIV Screening Tool for Children 18 Months To 14 Years as Efficient as Index Testing in Uganda
#7 Rhoderick Machekano, United States
Point of Care Samba-Ii Vs Centralized Laboratory Viral Load Assays Among HIV-1 Infected Children, Adolescents and Young Adults in Rural Zimbabwe: A Randomized Controlled Trial
#8 Vinie Kouamou, Zimbabwe
“Right Under Our Nose”: A Simple Screening Tool to Identify HIV-Positive Children Outside of the PMTCT Program at Outpatient Departments in Malawi
#9 Anna Tallmadge, Malawi
Finding the Remaining Unidentified Children Living with HIV: Opportunities Through Index Testing
#10 Megan Gleason, United States
Factors Associated with Late Presentation of HIV-Infected Infants for Early Infant HIV Diagnosis (Eid) Services in Kenya
#11 Agnes Langat, Kenya
Discussion - Abstract Session 2: Diagnosis, Case-Finding, Retention and Viral Suppression in Children living with HV
Session 3: Clinical Case Presentations -
Clinical Case Presentations 1
Vanessa Rouzier
Vanessa Rouzier, MD
GHESKIO Centers, Haiti and Weill Cornell Center for Global Health, New York, USA
Nadia Sam-Agudu, MD, CTropMed
University of Minnesota / Institute of Human Virology Nigeria, United States / Nigeria
Thanyawee Puthanakit, MD
Chulalongkorn University, Thailand
Sharon Nachman, MD
SUNY Health Science Center Stony Brook / IMPAACT Network, United States
Clinical Case Presentations 2
Elizabeth Whittaker
Elizabeth Whittaker, PhD DTM&H MRCPCH
Imperial College London, United Kingdom
Nadia Sam-Agudu, MD, CTropMed
University of Minnesota / Institute of Human Virology Nigeria, United States / Nigeria
Thanyawee Puthanakit, MD
Chulalongkorn University, Thailand
Sharon Nachman, MD
SUNY Health Science Center Stony Brook / IMPAACT Network, United States
Session 4: Undetectable=Untransmittable - Relevance to Breastfeeding -
Is U=U Applicable to Breastfeeding?
Lynne Mofenson, MD
Elizabeth Glaser Pediatric AIDS Foundation, United States
Guided poster tour 1: Pediatrics HIV Diagnosis and Treatment
Trends in Pediatric Antiretroviral Treatment in U.S. President’s Emergency Plan for AIDS Relief-Supported Countries in Sub-Saharan Africa —2016─2019
#30 Elizabeth Rabold, United States
Model Informed Prediction of Dolutegravir Pharmacokinetics in the Neonates
#31 Hardik Chandasana, United States
Absence of Selection for Integrase Inhibitor Resistance via tff he Q148H Pathway in HIV-1 Subtype F Integrases: Evaluation of Treatment Outcomes, Replicative Capacity, and Drug Resistance
#32 Mijael Rozenszajn, Argentina
Expanded Index Testing and Community-Based Testing Modalities in Nigeria Are Effective in Identifying Children Living with HIV
#33 Ariana Traub, United States
Evaluating the Performance of the Genexpert HIV-1 Qualitative Assay as a Consecutive Test for a New Early Infant Diagnosis Algorithm
#34 Aurélie Mukendi, South Africa
Guided poster tour 2: Adolescents and HIV
Change in Sexual Behavior and Partner Communication Following Oral HIV SelfTesting Among Adolescents and Young Adults in Kenya
#35 Matthew Driver, United States
High Rates of Primary and Secondary Syphilis Infections in HIV-Positive Adolescent and Young Adult Men Who Have Sex With Men in Atlanta, GA
#36 Leah Loerinc, United States
Overlapping Significant Life Events are Associated with HIV Viral Non-Suppression Among Youth in Clinics in Rural East Africa
#37 Florence Mwangwa, Uganda
Qualitative Analysis of a Mobile Whatsapp Group Messaging Intervention for Adolescents Living with HIV in Kenya
#38 Ashley Chory, United States
High Prevalence of Asymptomatic Sexually Transmitted Infections at Baseline Clinic Visit Following HIV Diagnosis in Atlanta Youth
#39 Amy Scheel, United States
Guided poster tour 3: Prevention of Mother-to-Child HIV Transmission
Cascades of Care for Preventing Vertical HIV Transmission in Canada
#40 Shu Nan Jessica Li, Canada
Opportunity Analysis for HIV Risk and Acquisition Among Pregnant Adolescent Girls and Young Women in Antenatal Care Services in Ten African Countries
#41 Cosima Lenz, United States
Continuous Quality Improvement Improves Retention of Clients in Prevention of Mother-To-Child Transmission of HIV Program (Wakiso District, Uganda)
#42 Grace Margaret Naikazi, Uganda
Higher Prevalence of Stunting and Lower Length, Weight, and Head Circumference among HIV-Exposed Uninfected Infants
#43 Jillian Neary, United States
Adoption of WHO’s HIV Retesting Policy for HIV-Negative Women During the Breastfeeding Period in 10 High HIV-Burden African Countries
#44 Barbara Burmen, South Africa
Guided poster tour 4: Pediatrics HIV Care and Monitoring
The Changing Face of Paediatric HIV: A Review of the Evolving Clinical Characteristics of a Paediatric and Adolescent Patients at a Clinic in Johannesburg, South Africa
#45 Josephine Keal, South Africa
Cognitive Outcomes at 7 and 9 Years After the Children with HIV Early Antiretroviral (CHER) Trial
#46 Kaylee van Wyhe, South Africa
HIV Prevalence and Clinical Cascade among Children 0-14 Years in Kenya: Results from a Population-Based Cross-Sectional Survey
#47 Immaculate Mutisya, Kenya
Low Access To Viral Load Monitoring And Poor Virological Outcomes In Children And Adolescents Living With HIV In West Africa
#48 Désiré Lucien Dahourou, Burkina Faso
Time to Repeat Viral Load Testing Following an Unsuppressed Viral Load Among Adolescents and Young Adults in Kenya
#49 Cyrus Mugo, Kenya
Clinical Outcomes of Infants Identified HIV-Positive at Birth Through Routine Pointof- Care Early Infant HIV Diagnosis; A Pilot Program In Eswatini
#50 Philisiwe Ntombenhle Khumalo, Swaziland

Day 2 - Tuesday, 17 November 2020

Session 5: Pediatrics Session -
The “Why, When and How To” of HIV Disclosure: Perspectives From the North and South
Ann Petru, MD
UCSF Benioff Children's Hospital Oakland, United States
Regina Oladokun, MD, MPH
University of Ibadan, Nigeria
PrEP in Pregnancy and Breastfeeding: the Why, What and How
Jilian Pintye
Jilian Pintye, RN, MPH, PhD
University Washington Seattle, United States
Prevention of Mother To Child HIV Transmission - Global Gaps and Potential Solutions
Benjamin Chi
Benjamin Chi
University of North Carolina, United States
Panel Discussion - Session 5: Pediatrics Session
Session 6: Oral Abstracts Presentations - Simultaneous -
Abstract Session 3: Adolescents and HIV
Development and Validation of the HIV Adolescent Readiness for Transition Scale (HARTS)
#13 Brian Zanoni, United States
Point-of-Care Viral Load Testing Among Adolescents and Young Adults Living with HIV in Haiti: A Randomized Control Trial
#14 Lindsey Reif, United States
Antiretroviral Drug Transition and Adverse Event Monitoring among Adolescents 15 to 19 Years of Age in Kenya
#15 Maureen Syowai, Kenya
Bringing HIV and SRH Services Closer to Adolescents Girls and Young Women in Eswatini Through a Comprehensive Mobile HIV and SRH Package
#16 Sibongile Wusumani, Swaziland
Archived HIV-1 Drug-Resistance Variants in Cellular Reservoirs and its Determinants among Vertically-Infected Adolescents Failing Antiretroviral Therapy
#17 Joseph Fokam, Cameroon
Deficits Noted at 11 Years in Children with HIV Starting Early Antiretroviral Therapy in Fine Motor Dexterity and Auditory Working Memory
#18 Barbara Laughton, South Africa
Panel Discussion - Abstract Session 3: Adolescents and HIV
Abstract Session 4: COVID-19 in Children
A Multi-Country Analysis of the Impact of COVID-19 on HIV Services for Children and Adolescents Living with HIV
#19 Ariana Traub, United States
Challenges of Remdesivir Pediatric Development for SARS-Cov-2 Infection in a Pandemic
#20 Cheryl Pikora, United States
A Multi-Country Analysis of the Impact of COVID-19 on Uptake of Multi-Month Dispensing for Children Living with HIV on Antiretroviral Therapy
#21 Nimasha Fernando, United States
A Multi-Country Analysis of the Impact of COVID-19 on HIV Services for Pregnant and Breastfeeding Women and their Infants
#22 Alexandra Vrazo, United States
Use of a Walk-In HIV and STI Testing Model for at Risk Youth Ages 13 to 24 - Assessment of the Impact of the COVID-19 Pandemic on Testing Services
#23 Isabella Lopez, United States
Panel Discussion - Abstract Session 4: COVID-19 in Children
Abstract Session 5: Prevention of HIV Mother-to-Child Transmission
Extent of In Utero Transfer of Tenofovir from Mother to Fetus: A Paired Analysis of Hair Specimens Collected at Birth from a Cohort in the United States
#24 Jillian Pintye, United States
Children Who are HIV-Exposed and Uninfected Exhibit Immune Suppressive Plasma Biomarker Profiles
#25 Alka Khaitan, United States
Time to First Positive HIV-1 DNA PCR in Infants Infected with Subtype B HIV-1 is Delayed in the Presence of Maternal Antiretroviral Use
#26 Raji Balasubramanian, United States
Higher Hospitalization Rates in Children Born HIV-Exposed Uninfected in British Columbia, Canada, Between 1990 and 2012
#27 Shu-Nan Jessica Li, Canada
Longitudinal Evolution of Maternal Viral Loads During Pregnancy and Postpartum Among Women Living with HIV in South Africa
#28 Faith Moyo, South Africa
Maternal PrEP Use in HIV-Uninfected Pregnant Women in South Africa: Role of Stigma in PrEP Initiation and Persistence
#29 Alexander Moran, United States
Panel Discussion - Abstract Session 5: Prevention of HIV Mother-to-Child Transmission
Session 7: COVID-19 in Pediatrics -
Susceptibility and Ability to Transmit
Lynne Mofenson, MD
Elizabeth Glaser Pediatric AIDS Foundation, United States
School/Daycare
Moherndran Archary, MBChB, PhD
University of KwaZulu Natal, South Africa
MTCT
Daniele
Daniele De Luca, MD, PhD
AP-HP Université Paris Saclay, France
Clinical Illness Including MIS-C
Elizabeth Whittaker
Elizabeth Whittaker, PhD, DTM&H MRCPCH
Imperial College London, United Kingdom
SARS-Cov-2 Vaccines
Anthony Fauci
Anthony Fauci, MD
Director of the National Institute of Allergy and Infectious Diseases (NIAID) at the U.S. National Institutes of Health, United States
Panel Discussion - Session 7: COVID-19 in Pediatrics
Youth Discussion Panel
Fletcher
HIV/AIDS Rights Advocacy Association of Taiwan, Taiwan
Sasha
United Kingdom
Joyce
APYIN, Nigeria
Overview
Welcome

In the past decade, there has been impressive success in the prevention of mother-to-child HIV transmission. However, we have not eliminated the problem of pediatric HIV infection, and much work remains to be done. Research in pediatric, adolescent, and maternal HIV infections is often a neglected area at major scientific HIV conferences, yet it is critical to achieving an AIDS-free generation.

While we have highly effective interventions to prevent HIV transmission, implementation has been incomplete. In 2015, 1.8 million children were living with HIV and 150,000 were newly infected with the disease worldwide. Even with the continued scale-up of preventive services, it is estimated that 2 million children will need antiretroviral treatment (ART) in 2020. Unfortunately, children are substantially less likely than adults to be diagnosed, engaged in care, and to access life-saving ART.

The treatment of pediatric HIV infection, particularly of infants and young children, remains complex and problematic. Rapid growth and organ system maturation, as well as emotional and cognitive changes that occur across the developmental spectrum from infancy through adolescence, complicate drug development, and administration. Adherence outcomes in children have been less than robust and mental health and behavioral issues are emerging as critical to understand and address in order to ensure the success of long-term treatment. Additionally, while fewer infected children are being born, there are increasing concerns about the long-term impact of in utero and post-natal exposures to antiretroviral drugs for those children who escape HIV. Currently, an estimated 20% of all infants born in sub-Saharan Africa are exposed to HIV and antiretrovirals during pregnancy and the post-natal period.

Young people account for half of all new cases of HIV infection worldwide, with adolescent girls and young women disproportionately affected. In sub-Saharan Africa in 2015, three out of four newly infected adolescents aged 15–19 years were girls. Adolescents living with HIV have been a particularly difficult group to reach. HIV was the leading cause of death among adolescents living in Africa and the second-leading cause of death in adolescents globally. The uptake of HIV testing among adolescents has remained low. Programs struggle to reach and retain adolescents in care and adherence to treatment has special challenges.

The pediatric HIV cure agenda is an important emerging area of research. Early infant diagnosis is increasingly available globally, enabling the earlier identification of infection and provides new exciting opportunities to study acute infection in children and promising cure strategies. The HIV Pediatrics Workshop is the only meeting entirely devoted to research in the prevention and treatment of HIV infections in infants, children, and adolescents, making it the premier forum for the world’s leading researchers.

Local Chairs 2020
Ted Ruel
Ted Ruel, MD
Benioff Children's Hospitals, University of California, United States
Workshop Chairs
General Information 
COVID-19 Update
The International Workshop on HIV Pediatrics was held as a virtual workshop from 16-17 November 2020. This way, we were able to welcome participants that encountered issues related to travel and/or health concerns.

We are available to answer any questions or concerns that you may have about your participation. For more information, please contact Rikke Rode at Rikke.Rode@amededu.com

Please stay tuned for future announcements regarding the format of the International Workshop on HIV Pediatrics. Make sure you are signed up for our newsletter.
Unique Features
- Research in prevention and treatment of HIV in pregnant/lactating women, infants, children, and adolescents are discussed

- A good representation of all organizations involved in HIV treatment and care in HIV Pediatrics

- Special Session to address most recent research

- Young investigator awards for best oral presentation and best poster presentation.

- 6 dedicated poster walks

- 28 (mini-) oral presentation

- An extraordinary record of supporting scientific achievement as demonstrated in the success across the cascade from abstract presentation to publication
Meeting Objectives
This meeting aims to:

- Providing updates on the latest research into new pediatric antiretroviral drugs, treatment, and cure strategies in children and adolescents

- Understanding of available prevention technologies and their application for prevention of HIV in adolescents in high- and low-resource settings; this information may translate into preventive interventions for high-risk adolescents in different settings

- Sharing results from implementation science research on how to optimally implement proven interventions for prevention of mother-to-child HIV transmission and pediatric care and treatment in developing countries

- Understanding risks of HIV transmission to pregnant and lactating women and implications for the child

- Evaluating optimal antiretroviral therapy in pregnancy and breastfeeding, the effect of such treatment on pregnancy and infant outcome, and potential long-term effects of HIV and antiretroviral exposure on the HIV-exposed but uninfected child as they age

- Understanding complications and comorbidities of long-term HIV infection and its therapy, in order to improve management of HIV in children

- Enhancing communication and collaboration between both junior- and senior-level, international researchers (from academia, government, and industry) and clinicians to promote the exchange of ideas, results, and technologies leading to successful translation into prevention and treatment of HIV

- Disseminating knowledge and data exchanged by workshop participants beyond the audience of the event through posting of all presentations on the workshop website, thus maximizing the impact of the workshop by reaching the whole HIV research community
Learning Objectives
After participating in this activity, participants will be able to:

- Describe the diversity of the HIV pediatric epidemic worldwide

- Summarize optimal treatment and management strategies of HIV infection in infants, children, and adolescents

- Describe innovations in pediatric treatment, including new drugs, new formulations, and new modalities such as immune-based treatment

- Outline treatment options for HIV-positive women during pregnancy and breastfeeding

- Describe the latest research on potential pediatric HIV cure and remission

- Describe major co-infections in HIV-positive children, such as tuberculosis and hepatitis, and their management

- Describe the special issues related to HIV infection in adolescents and young people, and HIV prevention and programming options for youth

- Reflect on potential effects of HIV in utero or post-natal antiretroviral exposure on HIV-exposed but uninfected children

- Describe models of optimal HIV program implementation of prevention and treatment in infants, children, adolescents, and pregnant and lactating women
Practical Information 
Certificate of Attendance
A certificate of attendance was sent to participants after successfully completing the workshop and post-workshop survey.
Language
The official language of the workshop was English
Translation was not provided.
Disclaimer
This workshop is intended for educational purposes only and aims to offer participants the opportunity to share information. The Organizing Secretariat of this event, Virology Education, cannot accept any liability for the scientific content of the sessions or for any claims which may result from the use of information or publications from this meeting. Virology Education disclaims all liability for injuries or losses of whatever nature incurred by individuals attending the workshop.
Liability and Insurance
By registering for the workshop, participants agree that the organizers do not accept responsibility for medical-, travel- or personal insurance. Participants are advised to take out their own insurance policies.
Photographs, Audio, and Video Recording
Photographs, audio, and video recordings are not permitted at the official workshop sessions. Only the official medical writer appointed by the organization may make recordings. All presentations will be posted here as soon as possible after the workshop is finished, provided that the speaker has given permission to do so.
Committees
Local Chairs 2020
Ted Ruel
Ted Ruel, MD
Benioff Children's Hospitals, University of California, United States
Workshop Chairs 2020
Committee Members
Patricia Flynn
Patricia Flynn, MD
SJCRH; University of Tennessee Health Science Center

The members of the Organizing Committee are a group of carefully selected experts and inspirational leaders in their respective fields. They meet frequently to discuss the scientific program of the workshop, identify interesting topics and candidate speakers, and review all submitted abstracts.

Scientific Committee

We are proud to present the members of the committee:

  • Moherndran Archary, MBChB, DOH, FCPaeds, University of KwaZulu Natal, South Africa

  • Jason Brophy, MD - Children's Hospital of Eastern Ontario, Canada

  • Ellen Chadwick, MD - Childrens Memorial Hospital, United States

  • Tsungai Chipato, MBChB - University of Zimbabwe College of Health Sciences, Zimbabwe

  • Polly Clayden - HIV i-Base, United Kingdom

  • Anita De Rossi, PhD - AIDS Reference Center, Italy

  • Marinella Della Negra, MD - Hopital Emilio Ribas, Brazil

  • Brian Eley, MD - Red Cross Children's Hospital, Department of Pediatrics, South Africa

  • Albert Faye, PhD - Denis Diderot University, Paris, France

  • Rashida Ferrand, MBBS, MRCP, MSc, DRM&H - London School of Hygiene & Tropical Medicine, United Kingdom

  • Tessa Goetghebuer, MD - Hôpital St Pierre, Belgium

  • Ali Judd, PhD, London School of Hygiene and Tropical Medicine, United Kingdom

  • Valériane Leroy, MD - Inserm, Paris, France

  • Chewe Luo, MD, PhD - UNICEF, United States

  • Dorothy Mbori-Ngacha, MBChB, MMed, MPH - United Nations Children's Fund, South Africa

  • Sharon Nachman, MD - SUNY Health Science Center Stony Brook, United States

  • Paul Palumbo, MD - Dartmouth-Hitchcock Medical Center, United States

  • Martina Penazzato, MD, DTMH, MSc, PhD - WHO, United Kingdom

  • Jorge Pinto, MD, DSc - School of Medicine, Federal University of Minas Gerais, Brasil

  • Natella Rakhmanina, MD, PhD, FAAP, AAHIV - Children's National Medical Center, United States

  • Theodore Ruel, MD - University of California, San Francisco, United States

  • George Siberry, MD, PhD - National Institute of Health, United States

  • Lynda Stranix-Chibanda, MBChB, MMED - University of Zimbabwe, Zimbabwe

  • Tavitiya Sudjaritruk, MD, ScM, PhD - Chiang Mai University, Thailand

  • Graham Taylor, MD - Imperial College, United Kingdom

  • Claire Thorne, BA, MSc, PhD - University College London, United Kingdom

  • Marissa Vicari - International AIDS Society, Switzerland

  • Rachel Vreeman, MD, MS - Icahn School of Medicine at Mount Sinai, United States

The members of Scientific Committee are hand-picked by the Organizing Committee and the conference secretariat based on their significant contributions and commitment to the field. They assist the Organizing Committee by providing them with suggestions for speakers and topics. In addition, members of the Scientific Committee participate in reviewing submitted abstracts, and play an active role during the workshop as moderators and/or chairs of sessions.

Support
Platinum Level
Gold Level

The 12th International Workshop on HIV Pediatrics is supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R13HD103495.

Endorsers
Language