AntiviralPK
Meeting category
Date(s)
19 Sep 2022 - 20 Sep 2022
Program Language
English
Location
Barcelona, Spain
Meeting type
Hybrid
Organizer

International Workshop on Clinical Pharmacology of HIV, Hepatitis, and Other Antiviral Drugs 2022

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Enduring Materials

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Day 1: Monday, 19 September 2022
Opening of the Workshop - 10:00
Opening Lecture: PrEP and Monkeypox in Spain
Pep Coll, MD
AIDS Research Institute-IrsiCaixa, Spain
Opening Session: Clinical Pharmacology of COVID-19 and Emerging Viruses -
Chairs
Alice Tseng, B.Sc.Phm., PharmD, FCSHP, AAHIVP
Toronto General Hospital, University of Toronto, Canada
Pep Coll, MD
AIDS Research Institute-IrsiCaixa, Spain
Emerging Strategies for Treating and Preventing Monkeypox
Ruth Byrne, MD
Chelsea and Westminster Hospital NHS Foundation Trust, United Kingdom
Current COVID-19 Therapies and Variants
Stefano Bonora, MD
University of Torino, Italy
DDIs Relevant for COVID-19 Therapeutic Agents & Implementation Challenges
Fiona Marra, FRPharmS
University of Liverpool, United Kingdom
Discussion
Session 1: Abstract-Driven Session -
Chair
Marta Boffito, MD, PhD, FRCP, MBA
Chelsea and Westminster Hospital NHS Foundation Trust; Imperial College London; United Kingdom
David Burger, PharmD, PhD
Radboud UMC, The Netherlands
#1: Predicting pharmacokinetics of nirmatrelvir/ritonavir in pregnant patients using physiologically based pharmacokinetic modelling.
Erica Leertouwer
Radboud Institute of Health Sciences, the Netherlands
#2: Pharmacokinetics of sotrovimab, a monoclonal antibody for early treatment of mild-to-moderate COVID-19
Asma El-Zailik
Vir Biotechnology, United States
#3: Pharmacokinetics of the small interfering RNA (siRNA) JNJ-73763989 and capsid assembly modulator (CAM) JNJ-56136379 in patients with chronic hepatitis B (CHB): REEF-1 and REEF-2 pharmacokinetic substudy (No 3)
Thomas Kakuda
Alios BioPharma, United States
#4: A Phase 1 Drug-Drug Interaction Study to Investigate the Potential Interaction Between ATI-2173 When Co-administered With Midazolam or Clarithromycin in Healthy Subjects
Myreen Tomas
Antios Therapeutics, United States
Discussion
Session 2: Debate - Is the End in Sight for Oral PrEP Therapies? -
Chairs
José Moltó, MD, PhD
Hospital Universitari Germans Trias i Pujol, Spain
Saye Khoo, MD, PhD
Royal Liverpool University Hospital; University of Liverpool, United Kingdom
Opening Words
Voting
PRO Healthcare Provider: Long-Acting Injectables for PrEP
Steve Taylor, MBChB, FRCP, PhD
Birmingham Heartlands Hospital, United Kingdom
CON Healthcare Provider: Oral Daily and/or On Demand PrEP
Laura Waters, MD, FRCP
Central & North West London NHS Foundation Trust, United Kingdom
Community Perspective
Michael Meulbroek
BCN Checkpoint, Spain
Policy Perspective
Heather-Marie Schmidt, BMedSc (Hon), MPH, PhD
UNAIDS Regional Office for Asia and the Pacific, Thailand and the Global HIV, Hepatitis and STIs Programme, World Health Organisation, Switzerland
Discussion with the Audience
Rebuttal (3 min/group - PRO and CON)
Voting
#5: A New Algorithm to Improve Adherence Classification Using Dried Blood Spots for Daily and Event-Driven PrEP
Aaron Devanathan
University of Pittsburgh, United States
#6: Long-acting Cabotegravir Pharmacokinetics With and Without Oral Lead-in for HIV PrEP
Kelong Han
GlaxoSmithKline, United States
Session 3: Pharmacological Developments With New & Old Viral Infections -
Chair
Rodolphe Garraffo, PharmD, PhD
Centre Hospitalier Universitaire de Nice, France
Andrea Calcagno, MD, DTM&H
University of Torino, Italy
Pharmacology Considerations of Future ART/PrEP Regimens
Marta Boffito, MD, PhD, FRCP, MBA
Chelsea and Westminster Hospital NHS Foundation Trust; Imperial College London; United Kingdom
Recent Developments in Antivirals Against Herpes Simplex Virus Infection
Scott H. James, MD
University of Alabama at Birmingham, United States
What’s on the Horizon for Direct Acting Antivirals for Hepatitis B?
Jennifer Kiser, PharmD, PhD
University of Colorado, United States
Discussion
ViiV Symposium: Early Pharmacology of Cabotegravir - Implications for Treatment and Prevention -
Chairs
Jonathan Schapiro, MD
National Hemophilia Center, Sheba Medical Center, Israel
Charles Flexner, MD
Johns Hopkins University School of Medicine, United States
Opening Words
Long-acting Cabotegravir for Treatment and Prevention: When Are You Protected?
Marta Boffito, MD, PhD, FRCP, MBA
Chelsea and Westminster Hospital NHS Foundation Trust; Imperial College London; United Kingdom
Clinical Implications of Cabotegravir Plasma Levels
Charles Flexner, MD
Johns Hopkins University School of Medicine, United States
The Non-adherent Patient: A Good or Bad Candidate for CAB+RPV?
Jose Castillo-Mancilla, MD
University of Colorado School of Medicine, United States
Discussion
Closure of the Symposium
Day 2: Tuesday, 20 September 2022
Session 4: Opening Pharmacological Considerations in Key Populations     -
Chairs
Tim Cressey, MSc, PhD
Chiang Mai University, Thailand
Edmund Capparelli, PharmD
University of California, San Diego (UCSD), United States
Age-Related Changes in Pharmacokinetics and Pharmacodynamics
Catia Marzolini, PharmD, PhD
University Hospital of Basel, University Hospital of Lausanne, Switzerland; University of Liverpool, United Kingdom
Pharmacology Pearls for Managing Absorption and Swallowing Difficulties
Saye Khoo, MD, PhD
Royal Liverpool University Hospital; University of Liverpool, United Kingdom
Optimization of Pharmacology Studies and DDIs in Pregnant and Lactating Individuals
Angela Colbers, PhD
Radboudumc, the Netherlands
Discussion
Session 5: Abstract-Driven Session -
Chair
Catriona Waitt, MBChB, PhD
University of Liverpool, United Kingdom
Angela Colbers, PhD
Radboudumc, the Netherlands
#7: Physiologically-Based Pharmacokinetic Modelling of Long-Acting Cabotegravir in Pregnancy Suggests That Dose Adjustment Might Not Be Necessary
Shakir Atoyebi
University of Liverpool, United Kingdom
#8: Pharmacokinetics of First-line Tuberculosis Drugs in Pregnant and Postpartum Women without HIV and Women with HIV on Efavirenz-based Antiretroviral Treatment
Marije Van Schalkwyk
Stellenbosch University / Tygerberg Hospital, South Africa
#9: TFVdp in Cervical Tissue in Pre- And Post- Menopausal Women on TAF and TDF
Alyssa Lantz
University Of Minnesota, United States
#10: Doravirine Exposure in Obese Population Living With HIV Infection (Double Study): Data From Physiologically-Based Pharmacokinetics Modelling and Real-Life Patients
Leena Zino
Radboudumc, the Netherlands
Discussion
Charles Boucher Memorial Lecture -
Chair
Jonathan Schapiro, MD
National Hemophilia Center, Sheba Medical Center, Israel
Pharmacokinetics of mAbs in Prevention, Treatment and Cure of Viral Infections
Edmund Capparelli, PharmD
University of California, San Diego (UCSD), United States
#11: Plasma, Intracellular and Lymph node Antiretroviral Concentrations and HIV DNA Change in Patients Treated During Primary HIV Infection: Results from the INACTION P25 Study
Amedeo De Nicolò
Università Degli Studi Di Torino, Italy
Session 6: Abstract-Driven Session    -
Chairs
Catia Marzolini, PharmD, PhD
University Hospital of Basel, University Hospital of Lausanne, Switzerland; University of Liverpool, United Kingdom
Caroline Solas Chesneau, PharmD, PhD
University Hospital of La Timone, Aix-Marseille University, France
Endogenous Biomarker Informed Approach to Assess Potential for Transporter Mediated Drug-Drug Interactions: Concepts, Applications, Knowledge Gaps
Vikram Arya, PhD, FCP
Food and Drug Administration, United States
#12: Deep Learning Ensemble Classifier to Predict Drug-Drug Interaction
Thao Pham
University Of Liverpool, United Kingdom
#13: Population Pharmacokinetics of the Levonorgestrel Implant in Combination With Four Antiretroviral Therapies
Michelle Pham
University of Nebraska Medical Center, United States
Discussion
Session 7: New Drug Detection and Delivery Technologies -
Chairs
Melanie Nicol, PharmD, PhD
University of Minnesota, United States
​​​​​​​Peter L. Anderson, PharmD
University of Colorado, Anschutz Medical Campus, United States
Multipurpose Prevention Technologies (MPTs) For Prevention of HIV and Pregnancy
Sharon L. Hillier, PhD
Magee-Womens Hospital of UPMC, United States
Strategies to Improve Delivery to Reservoirs as Targets for Long-Acting Antivirals
Adeniyi Olagunju, BPharm, MRes, PhD
University of Liverpool, United Kingdom
Point of Care Tests for Drug Level Testing: Where Are We?
Paul K. Drain, MD, MPH, FIDSA
University of Washington, United States
#14: Tenofovir Diphosphate in Dried Blood Spots in Persons With HIV Taking Tenofovir Alafenamide as Digital Pills: Preliminary Data From the QUANTI-TAF Study
Ryan Coyle
University of Colorado-AMC, United States
Discussion
Session 8: Roundtable Discussion: Unexpected Pitfalls of Long-Acting Agents -
Chairs
Kimberly Scarsi, PharmD, MS, FCCP
University of Nebraska Medical Center (UNMC), United States
Steve Taylor, MBChB, FRCP, PhD
Birmingham Heartlands Hospital, United Kingdom
Short Talk: Islatravir Toxicity
Charles Flexner, MD
Johns Hopkins University School of Medicine, United States
Short Talk: Cabotegravir/Rilpivirine Failures Despite Adherence
Jose Castillo-Mancilla, MD
University of Colorado School of Medicine, United States
Short Talk:  Lenacapavir Considerations
Jonathan Schapiro, MD
National Hemophilia Center, Sheba Medical Center, Israel
Panel Discussion
Language
Ratings previous edition
Content is relevant to my practice
4.7
(40)
Content was free from commercial bias
4.8
Overall event experience
4.7