Hepatitis B

Hepatitis and liver disease

Date(s)

13 Nov 2024

Program Language

English

Location

San Diego , United States

Meeting type

In-person Workshop

Organizer

International Workshop on HBV Cure 2024

Related Enduring Materials

General

What's New

HBV Cure 2024 took place as an in-person workshop on 13 November in San Diego, US. Enduring Materials will be available shortly.
The International Workshop on HBV Cure 2024 was fully compliant by EthicalMedTech, underscoring our commitment to maintaining the highest ethical standards.

To stay updated on the latest developments, make sure you are signed up for our newsletter.

Welcome

The International Workshop on HBV Cure 2024 took place in San Diego, US, on Wednesday 13 November 2024 - just before the AASLD liver meeting.

Since 2014, the International Workshop on HBV Cure has been a scientific platform acting as a catalyst to accelerate the progress for achieving a cure. Around the globe, more than 250 million people live with hepatitis B (HBV). The purpose of the workshop is to inform the participants about the developments in the work to find a cure for HBV. The meeting will be highly interactive with input from experts out of the arena of basic, translational, and clinical HBV research.

The field of HBV treatment is undergoing major changes and is on the verge of a paradigm shift. The many new treatment options that are becoming available provide great hopes for decreasing the burden of the disease, simplifying treatment, and potentially curing and eradicating HBV infection.

In order to optimize curative treatment for HBV, outstanding speakers from around the globe will share the newest therapeutic options for viral hepatitis, and experts will discuss the path forward to cure this deadly disease, leading to liver cirrhosis and liver cancer. Questions on which endpoints to use in therapeutic trials and how to combine different agents targeting the virus and/or immune system will be extensively discussed.

This workshop also brings together global inter-disciplinary experts to provide a framework for how academia and industry should collaborate to achieve the goal of curing hepatitis B.

Program Directors

Harry Janssen, MD, PhD

Erasmus MC, University Hospital Rotterdam, the Netherlands / Toronto Centre for Liver Disease, Canada

Adam Gehring, PhD

Toronto Centre for Liver Disease, Canada

General Information

Venue

The confirmed venue for the HBV Cure 2024 is at the following location:

Horton Grand Hotel
311 Island Avenue
San Diego 92101
California

Distance from San Diego International Airport: 5.5 km (10 minutes)

Unique Features

- Invited lectures from international experts

- Interactive roundtable discussions

- Ample time for discussion

Who should attend?

- Clinicians
- Researchers
- Academia
- Industry
- Government representatives

Meeting Objectives

The objectives of this workshop are to:

- Discuss how to reach an HBV functional cure with newly developed agents targeting the immune system or the viral replication cycle;
- Develop endpoints and better biomarkers for these studies; and
- Discuss how new agents should be combined to reach the goal of a functional cure.

Code of Conduct

All attendees, speakers, co-organizers, partners, endorsers, suppliers, volunteers, and employees at any of our programs are expected to observe our Code of Conduct. We cannot tolerate any form of discrimination, harassment, disrespect, or the marginalization of those involved in our programs. All participants of VE and AME-organized programs are expected to treat others with dignity and respect at all times.

Any individual who feels discriminated against, harassed, disrespected, or marginalized is encouraged to report the incident(s) to VE and AME via info@amededu.com or to one of our on-site personnel.

Any participant who is found to have exhibited any inappropriate conduct or behavior against others may be removed from the program.

Practical Information

Certificate of Attedance

A certificate of attendance will be sent to participants that successfully complete the program and post-meeting survey.

Language

The official language of the meeting is English.

Accomodation

Accommodation is not included in the registration fee.

Photographs, Audio, and Visual Recording

Photographs, audio, and video recordings are not permitted at the official workshop sessions. Only the official medical writer appointed by the organization may make recordings. All presentations will be posted here as soon as possible after the workshop is finished, provided the speaker has given permission to do so.

Liability and Insurance

By registering for the workshop participants agree that the organizers do not accept responsibility for medical-, travel- or personal insurance. Participants are advised to take out their own insurance policies.

Disclaimer

This workshop is intended for educational purposes only and aims to offer participants the opportunity to share information. The Organizing Secretariat of this event, AME and VE, cannot accept any liability for the scientific content of the sessions or for any claims which may result from the use of information or publications from this meeting. AME and VE disclaim all liability for injuries or losses of whatever nature incurred by individuals attending the workshop.

Registration

Registration for the International Workshop on HBV Cure 2024 is open.

Fees & Conditions

	Regular Delegates - On-site	Industry - On-site
Early Fee (payment before/on 31 May 2024 )	$ 475	$ 715
Standard Fee (payment before/on 15 September 2024)	$ 715	$ 1055
Late Fee (Payment from 16 September 2024)	$ 835	$ 1.175

Regular Delegates

On-site

Industry

On-site

Early Fee (payment before/on 31 May 2024 )

$ 475

$ 715

Standard Fee (payment before/on 15 September 2024)

$ 715

$ 1055

Late Fee (Payment from 16 September 2024)

$ 835

$ 1.175

Discounts
Early-career investigators /Regular Delegates from Resource-Limited Settings (RLS)**	50% Off Current Regular Fee
NGO Representatives / Government Representatives (i.e. MOH, NIH, NIAID, etc.) / Advocates	50% Off Current Regular Fee
Representatives of sponsoring industry / endorsing organizations ***	Please contact the conference secretariat
People living with hepatitis B (HBV)	100% discount on the current regular fee

** Countries included in the low-income and lower middle-income economies of the World Bank Classification.

*** Industry and endorser representatives may receive a discount based on the level of support provided to the event. For more support and registration information, please contact us via B renda.Evan@amededu.com

If you have financial concerns or are eligible for a discount, please contact the conference secretariat via Karen.Lam@amededu.com.

IMPORTANT

AME (Academic Medical Education) reserves the right to cancel improper registrations. Claims for a refund will not be honoured.
We strongly advise that you register early to ensure your registration is secured.
Submission of your online registration does not guarantee that your registration has been accepted. Your registration is final when full prepayment has been received and a confirmation of your registration has been sent.

Registration Fee Includes

For onsite attendees:

- Access to all scientific sessions, including poster area

- Conference pack, including abstract book and program

- Refreshments during the coffee breaks

- Buffet lunch on meeting days

IMPORTANT:

- No day rate is available

- Payment can only be made by credit card.

- Virology Education reserves the right to cancel improper registrations. Claims for a refund will not be honored.

Group Registration

For registration of groups larger than 5 participants, please use the Group Registration Portal.

Early-Career Investigators / Academia from Resource-limited Settings (RLS)

We are pleased to waive the registration fee for early-career investigators and academia from low-income and lower-middle-income countries with an accepted abstract and a 50% discount on the registration fee without an accepted abstract.

IMPORTANT: The fee waiver is offered to the presenting author only.

To be eligible as an early-career investigator, one should either be a current Master/PhD student or have obtained an MD/PharmD/PhD degree in the last five years. An application form needs to be completed by a supervisor and received by the Virology Education secretariat at least two weeks prior to the start of the workshop. Virology Education will contact the early-career investigator with instructions regarding the registration procedure.

Payment

By credit card only: online or by written authorization (see online registration).

Cancellation Policy

In case of cancellation, the following refunds are applicable:

- Cancellation before/on one month before the workshop: 50% refund (minus an administration fee of $40)

- Cancellation after that date: Unfortunately, no refund will be given

If you are unable to attend the conference, a substitute delegate is always welcome at no extra charge, provided that a letter of authorization from the original participant has been received and the conference secretariat has been notified of the name of the substitute delegate two weeks before the workshop. A statement (email/letter) of cancellation must be sent to Virology Education.

Liability and Insurance

By registering for the conference, participants agree that the organizers do not accept responsibility for medical, travel, or personal insurance. Participants are advised to take out their own insurance policies.

Media Registration

In order to register as a media participant for the workshop, the conference secretariat needs to receive:

1. Proof of accreditation
2. Valid identification (e.g. passport)
3. A letter from your assignment giver stating the details of your assignment (e.g. editor)
4. At least 3 previous written assignments in recognized outlets on HIV. If you are a freelance journalist, the assignments can be from different (recognizable) news outlets. Links to online publications are accepted
5. The website of the publication(s)/blog(s) that will be featuring your story on this workshop

A free or reduced registration fee may apply for accredited media participants depending on availability. Preference will be given to credible print and online news sources. Please contact the conference secretariat for registration conditions.

We would like to receive a copy of your workshop report/ article once it is finalized.
All credentials will be verified by the Organizing Committee of the Workshop. Media representatives are kindly requested to register by sending the above-mentioned information to info@amededu.com.

Important: Media is restricted to the written press. Recording on film or photo is not allowed. Virology Education will request a copy of the written piece once it is finalized. Media representatives must also agree to abide by the 2021 embargo policy.

Disclaimer

This workshop is intended for educational purposes only and aims to offer participants the opportunity to share information. The organizing secretariat of this workshop, Virology Education, cannot accept any liability for the scientific content of the sessions or for any claims which may result from the use of information or publications from this workshop. Virology Education disclaims all liability for injuries or losses of whatever nature incurred by individuals attending the workshop. In case of cancellation of the meeting due to unforeseen circumstances, Virology Education cannot be held responsible for expenses made for travel, accommodation, visa applications, etc.

Downloads:

HBV Cure 2024_Early Career Investigator Application Form.docx

HBV Cure 2024_RLS application form.docx

Program

Virtual Program Book | HBV Cure 2024

Download the Program Book

Wednesday, 13 November

Opening - 8:30

8:30 AM

Welcome

Session 1: Predictors of Treatment Outcome -

Session Chairs

Robert Gish, MD

Hepatitis B Foundation and the American Pacific Health Foundation, California, United States

Carla S. Coffin, MD, MSc, FRCPC, FAASLD

Cumming School of Medicine; University of Calgary; Viral Hepatitis Clinic, Canada

8:40 AM

RNA Interference Combined with Immune Modulation: Are There Clinical Features That Identify HBsAg Loss?

Ed Gane, MBChB, MD, FRACP, FAASLD, MNZM

University of Auckland, New Zealand

9:00 AM

Sustainability of HBsAg Loss After Treatment: When Do We Call It Functional Cure?

Harry Janssen, MD, PhD

Erasmus MC, University Hospital Rotterdam, the Netherlands / Toronto Centre for Liver Disease, Canada

9:20 AM

Immunological Editing to Drive HBsAg Production from Integrated HBV DNA vs. Infected Hepatocytes

Adam Gehring, PhD

Toronto Centre for Liver Disease, Canada

9:40 AM

Discussion

10:10 AM

Coffee Break

Session 2: Intrahepatic Insights and Peripheral Biomarkers of Therapeutic Mechanisms of Action -

Session Chairs

Pietro Lampertico, MD, PhD

University of Milan, Italy

Maura Dandri, PhD

University of Hamburg, Germany

10:30 AM

Insights from Intrahepatic Analysis in Clinical Trials for Chronic Hepatitis B

Jordan Feld, MD, MPH

Toronto Centre for Liver Disease, Canada

10:50 AM

Intrahepatic Landscape in the Delta-Infected, Bulevirtide-Treated Liver

Maura Dandri, PhD

University of Hamburg, Germany

11:10 AM

Next Generation Tests for HBcAg and HBcrAg - Increased Sensitivity and Utility?

Mark Sulkowski, MD

Johns Hopkins University, United States

11:30 AM

Discussion

12:00 PM

Lunch

Session 3: Immunology and Immunotherapy -

Session Chairs

Adam Gehring, PhD

Toronto Centre for Liver Disease, Canada

Man-Fung Yuen, MBBS, MD, PhD, DSc

University of Hong Kong and Li Shu Fan Medical Foundation, Hong Kong

1:00 PM

Atypical Antibody and B Cell Responses in Chronic Viral Infection

Mansun Law, PhD

The Scripps Research Institute, United States

1:20 PM

Additive Benefit of Mab in siRNA + IFN-α Combinations

Carey Hwang, MD, PhD

Vir Biotechnology, Inc., United States

1:30 PM

PK and Efficacy of Unmodified MAb in Chronic Hepatitis B & D

Hassan Javanbakht, PhD

Bluejay Therapeutics, United States

1:40 PM

Therapeutic Vaccine with Novel Checkpoint Inhibition

Sue Currie, PhD

Virion Therapeutics, LLC, United States

1:50 PM

HBsAg Levels and T Cell Boost in Patients with HBsAg Decline

Nadège Pelletier, PhD

Barinthus Bio, United Kingdom

2:00 PM

TCR Gene Therapy in Clinical Application for Chronic Hepatitis B and HBV-Related HCC

Karin Wisskirchen

SCG Cell Therapy GmbH, Germany

2:10 PM

Discussion

2:40 PM

Coffee Break

Session 4: Virology and DAAs -

Session Chairs

Raymond Schinazi, PhD, DSc

Emory University Center for AIDS Research (CFAR), United States

Massimo Levrero, MD

Hopital de la Croix-Rousse, France

3:10 PM

Prospects for Gene Editing in CHB Cure Regimens

Fabien Zoulim, MD, PhD

Lyon I University / Hospices Civils de Lyon / INSERM, France

3:30 PM

Strategies and Potential for siRNA + ASO Combinations

Dickens Theodore, MD, MPH

GSK, United States

3:40 PM

Imdusiran Combinations Achieving HBsAg Loss

Karen Sims, MD, PhD

Arbutus Biopharma, United States

3:50 PM

Similarities and Differences in Using the TLR7 Agonist Ruzotolimod vs. PEGylated IFN-α in Combination with the HBV siRNA Xalnesiran

Rémi Kazma, MD, PhD

Roche Innovation Center Basel, Switzerland

4:00 PM

Efficacy of Cams across Patient Cohorts: HBeAg+ vs. HBeAg-

Tse-I Lin, D.Phil

Aligos Therapeutics, Belgium

4:10 PM

Durability of HDV RNA Loss vs Decline after Long-Term Bulevirtide Treatment / IFN + Bulevirtide - Curative Strategies for HDV

Dmitry Manuilov, MD

Gilead Sciences, Germany

4:20 PM

Discussion

4:50 PM

Closing Remarks

Harry Janssen, MD, PhD

Erasmus MC, University Hospital Rotterdam, the Netherlands / Toronto Centre for Liver Disease, Canada

Adam Gehring, PhD

Toronto Centre for Liver Disease, Canada

5:00 PM

End

17:00-18:00 PM

Networking Reception

Committees

Program Directors

Adam Gehring, PhD

Toronto Centre for Liver Disease, Canada

Harry Janssen, MD, PhD

Erasmus MC, University Hospital Rotterdam, the Netherlands / Toronto Centre for Liver Disease, Canada

Organizing Committee

Carla S. Coffin, MD, MSc, FRCPC, FAASLD

Cumming School of Medicine; University of Calgary; Viral Hepatitis Clinic, Canada

Pietro Lampertico, MD, PhD

University of Milan, Italy

Raymond Schinazi, PhD, DSc

Emory University Center for AIDS Research (CFAR), United States

Man-Fung Yuen, MBBS, MD, PhD, DSc

University of Hong Kong and Li Shu Fan Medical Foundation, Hong Kong

Fabien Zoulim, MD, PhD

Lyon I University / Hospices Civils de Lyon / INSERM, France

The members of the Organizing Committee are a group of carefully selected experts and inspirational leaders in their respective fields. They meet frequently to discuss the scientific program of the workshop and identify interesting topics and candidate speakers.

Scientific Program Coordinator

Maren Kleopfer

Scientific Program Coordinator, Academic Medical Education

Support

Silver Level

Bronze Level

Supporter

Friend Level

Support Our Initiative

Financial backing helps us deliver an impactful meeting experience for the benefit of healthcare professionals, researchers, and community representatives involved in HBV Cure.

This collaboration plays a vital role in both the organizational as well as scientific success of the program.

To show your commitment to the cause and get in touch with us for a tailored support package, please contact Brenda Evan via B renda.Evan@amededu.com.

Benefits of Support
By supporting this program, we can offer the following advantages for your company.* Please contact us for the most recent support level benefits for this program.

Symposium opportunities
Non-commercial interviews with company representatives
Verbal acknowledgment during the program
Discounted and complimentary registrations for your representatives
Company acknowledgment on digital meeting materials including but not limited to newsletters, flyers, the streaming platform, and our website
Company acknowledgment on printed meeting materials including but not limited to banners and the program book
Digital and printed advertising opportunities
Social media shout-outs
Logo on the conference bag

*Subject to the support level

Endorsers

A 25% discount on the meeting registration fee is offered to the members/employees of our endorsers. Please reach out to your organization for your discount code.

If you would like your organization to endorse HBV Cure, please contact Brenda Evan at Brenda.Evan@amededu.com

Workshop Partner

Media Partner

Endorsers

Media

Invitation to Join the International Workshop on HBV Cure 2024

Invitation from Harry Janssen, MD, PhD, Erasmus MC, University Hospital Rotterdam, the Netherlands / Toronto Centre for Liver Disease, Canada and Adam Gehring, PhD, Toronto Centre for Liver Disease, Canada.