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Date(s)

6 Sep 2023 - 7 Sep 2023

Program Language

English

Location

Rockville, MD, United States

Meeting type

Hybrid Meeting

Download the Program Book

Viral Infections & Inflammation Workshop 2023

Related Enduring Materials

Enduring Materials

5 Key Messages from VII Workshop 2022

Acute and chronic effects of viral diseases often involve immune-mediated responses, including inflammation, immune activation, and autoimmunity. Therapeutic interventions must often target both ends of the virus-immune system spectrum.
Statins reduce severe cardiovascular events in people with HIV, even in individuals with low baseline cardiovascular risk.
Long-COVID immunopathogenesis is complex but its understanding is advancing rapidly. The consequences of immune-mediated damage in long COVID share similarities (and differences) with other post-viral diseases like Ebola and MF/CFS
Viruses can also trigger autoimmunity. Epstein-Barr Virus is tightly linked with the onset of Multiple Sclerosis through several autoimmune mechanisms. Viral encephalitis also often has an autoimmune background
Immune therapies targeting the inflammasome or virus-specific CAR-T cells, among others, are advancing towards the cure of different acute and chronic viral diseases

Program

Day 1, Wednesday 6 September

Opening of the Workshop -

Plenary Talk: Update on the REPRIEVE Trial to Prevent Cardiovascular Events in People with HIV

Steven Grinspoon, MD

Harvard Medical School / Massachusetts General Hospital, United States

Video

Slideset

Session 1: Post-COVID Syndromes -

Viruses, Immune Dysfunction, and ME/CFS

Maureen R. Hanson, Ph.D.

Cornell University, United States

Video

Slideset

Underlying Mechanisms of Long COVID

Michael Peluso, MD

University of California, San Francisco, United States

Video

Slideset

(O_#1) High Levels of Il-1β, Tnf-α and Mip-1α One Month after the Onset of the Acute Sars-CoV-2 Infection, Predictors of Post COVID-19 in Hospitalized Patients

Jacobo Alonso-Domínguez

Galicia Sur Health Research Institute, Spain

Video

Slideset

(O_#2) Determinants of the Onset and Prognosis of the Post-COVID-19 Condition: A 2-Year Prospective Cohort Study

Roger Paredes

Irsicaixa Aids Research Institute, Spain

Video

Slideset

Satellite Symposium -

The Impact of Viral Glycoproteins on Inflammation and Immunity

Session 2: Post-infectious Syndromes -

Immune Signatures in Vaccine-Associated Myocarditis

Anis Barmada, MPhil

Yale University School of Medicine, United States

Slideset

What We Know Now about HIV and Long COVID

Annie Antar, MD, PhD

Johns Hopkins University School of Medicine, United States

Video

Slideset

Epstein–Barr Virus and Multiple Sclerosis: Which Mechanisms are at Play?

Tobias Lanz, MD

Stanford University, United States

Video

Slideset

(O_#3) A Role for Inflammasome Activation and Oxidative Stress in Sars-CoV-2 Breakthrough Infection and Symptomatic Rebound

Silvia Lucena Lage

NIH, United States

Day 2, Thursday 7 September

Session 3: Post-acute Sequelae Following Different Infections -

Post-acute Sequelae following Ebola infection

David Wohl, MD

UNC School of Medicine, United States

Video

Slideset

Endogeneous Retroviruses and Inflammation

Yasmine Belkaid, PhD

NIH/NIAID, United States

Video

(O_#4) HIV Exposed Uninfected (Heu) Infants Have Pro-inflammatory Bioprofiles That Correlate with Their Mothers’ Bioprofiles Independent of Viral Levels and Persist for at Least Six Months

Li Yin

NIAID, United States

Video

Slideset

(O_#5) Possible Role of Intestinal Damage and Endotoxemia in the Development of Endotholial Dysfunction, Thrombosis and Secondary Lung Damage in Patients with COVID-19

Liudmyla Shostakovych-Koretskaya

Dnipropetrovsk State Medical University, Ukraine

Video

Slideset

Session 4: Chronic Viral Infections and Inflammation-related Comorbidities -

HIV, Inflammation, and Macrophages

Maureen M. Goodenow, Ph.D.

NIAID/NIH, United States

Video

Slideset

Inflammation in People with Low Nadir CD4 Counts

Irini Sereti, MD

NIAID/NIH, United States

Acute Disseminated Encephalomyelitis

Arun Venkatesan, MD PhD

Johns Hopkins University School of Medicine, United States

Slideset

(O_#6) The Plasma Microbiome Contributes to Immune Reconstitution in HIV Infected Individuals on Suppressive ART

Wei Jiang

Medical University of South Carolina, United States

Video

Slideset

Session 5: Interventions Targeting Inflammation and Post-viral Syndromes -

Inflammasome Activation in Severe Cases of COVID-19

Dario Zamboni, Ph.D.

University of São Paulo, Brazil

Video

Slideset

Developing CAR T Cells for Use in Chronic HIV Infection

Martin Tolstrup, MSc, PhD

Aarhus University Hospital, Denmark

Video

Slideset

(O_#7) Impact of Glatiramer Acetate Treatment in SIVmac-Infected Macaques

Beatrice Jacqulin

Institut Pasteur, France

Overview

Thank you

We are pleased to look back on a very successful 2nd edition of the Viral Infections & Inflammation Workshop 2023, held from 6 - 7 September in Rockville, Maryland, USA.

The Organizing Committee and organizers would like to thank the speakers, chairs, and all participants for their contribution to this meeting! Special thanks to the workshop support: ViiV Healthcare and Merck. Without their contribution, this workshop would not have been made possible.

About this Program

The Viral Infections & Inflammation Workshop 2023 brought together basic, translational, and clinical researchers to disseminate the latest knowledge in this area and fuel discussion on the many remaining unknowns in order to catalyze future research.

Inflammatory response and cytokine storm in severely ill COVID-19 patients have put a spotlight on the importance of inflammation in viral infections. Prevalence of long-term COVID is also a concern and potentially related to the suboptimal function of the immune system. Yet, these concerns are not unique to COVID-19. In the case of HIV for instance, despite remarkable improvements in antiretroviral therapy, immune reconstitution remains limited in some patients even a long time after treatment initiation. Exhaustion of primary immune resources due to persistent activation and inflammation drives premature immune aging and impacts life expectancy.

Although HIV and SARS-CoV-2 are fundamentally different infections with distinct long-term consequences, underlying mechanisms that drive those complications might be common. Common underlying mechanisms imply the possibility to employ similar therapeutic interventions. For instance neutralizing antibodies, antiviral drugs, and therapeutic vaccines to eliminate the persistent virus or anti-inflammatory drugs to ameliorate chronic inflammation.

General Information

Who Should Attend?

Meeting Objectives

Learning Objectives

Practical Information

We trust that the following information will assist you in organizing your participation for the Viral Infections and Inflammation Workshop 2023.

Venue

Accommodation

Badges

Certificate of Attendance

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Disclaimer

Liability and Insurance

Photographs, Audio, and Video Recording

Code of Conduct

Symposium

Day 1 - Wednesday, 6 September 2023

Satellite Symposium: The Impact of Viral Glycoproteins on Inflammation and Immunity -

Immunopathology of Viral Encephalitis

Avindra Nath, MD

National Institutes of Health, United States

Video

Slideset

Immune Responses to AAV in the Context of Gene Therapy

Carsten Bönnemann, MD

NINDS/ NIH, United States

Host and Viral Glycoproteins in HIV Neuropathogenesis

Lishomwa Ndhlovu, MD, PhD

Weill Cornell Medicine, United States

Committees

Organizing Committee

Roger Paredes, MD, PhD

Hospital Germans Trias & IrsiCaixa AIDS Research Institute, Spain

Steven Deeks, MD

University of California, San Francisco, United States

Steven Grinspoon, MD

Harvard Medical School / Massachusetts General Hospital, United States

Anthony Kelleher, MBBS, PhD, FRACP, FRCPA

The Kirby Institute, Australia

Daniel Kuritzkes, MD

Brigham and Women's Hospital / Harvard Medical School, United States

Michaela Müller-Trutwin, PhD

Institut Pasteur, France

Avindra Nath, MD

National Institutes of Health, United States

Jonathan Schapiro, MD

National Hemophilia Center, Sheba Medical Center, Israel

Irini Sereti, MD

NIAID/NIH, United States

Serena Spudich, MD

Yale University, United States

The members of the Organizing Committee are a group of carefully selected experts and inspirational leaders in their respective fields. They meet frequently to discuss the scientific program of the workshop, identify interesting topics and candidate speakers, and review all submitted abstracts.

Support

Gold Level

Silver Level

Satellite Symposium

The Satellite Symposium: The Impact of Viral Glycoproteins on Inflammation and Immunity is supported by an independent educational grant from ViiV Healthcare.

ViiV Healthcare was not involved in the development of content or selection of faculty for this educational activity.

Support Our Initiative
Financial backing helps us deliver an impactful meeting experience to the benefit of healthcare professionals and researchers interested in HIV and inflammation.

This collaboration plays a vital role in both the organizational as well as scientific success of the program.

To show your commitment to the cause, get in touch with us for a tailored
support package by contacting Ms. Federica Ressa at Federica @amededu.com or call +31 30 2307147.

Benefits of Support
By supporting this program, we can offer the following advantages for your company.* Please contact us for the most recent support level benefits for this program.

Symposium opportunities
Non-commercial interviews with company representatives
Verbal acknowledgement during the program
Discounted and complimentary registrations for your representatives
Company acknowledgement on digital meeting materials including but not limited to newsletters, flyers, the streaming platform, and our website
Company acknowledgement on printed meeting materials including but not limited to banners and the program book
Digital and printed advertising opportunities
Social media shout-outs
Logo on the conference bag

*Subject to the support level.

Downloads:

Viral Infections & Inflammation Workshop 2023_Support Letter.pdf

Endorsers

The Viral Infections & Inflammation Workshop 2023 was endorsed by the following organizations:

Media

2023 Highlights

Hear Prof. Roger Paredes, MD, PhD (Hospital Germans Trias & IrsiCaixa AIDS Research Institute, Spain) deliver an insightful summary for clinicians on the take-home messages from the 2nd edition of the Workshop!