Prof. Grant Theron is a highly cited tuberculosis (TB) researcher and a Professor in the Division of Molecular Biology and Human Genetics at Stellenbosch University, South Africa. He is also the principal investigator of the Clinical Mycobacteriology and Epidemiology (CLIME) research group, which operates at the intersection of clinical, epidemiological, and molecular TB research. (https://www.sun.ac.za/english/faculty/healthsciences/Molecular_Biology_Human_Genetics/clinical_mycobacteriology_epidemiology/Pages/default.aspx)
Prof. Theron’s group is based in Cape Town, where they collaborate with local partners at multiple primary care facilities, secondary and tertiary hospitals, and specialised facilities focussed on ART-initiation and drug-resistant TB. Prof. Theron’s group also closely collaborates with the national reference laboratory, where he supervises several trainees.
Prof. Theron’s research has significantly shaped global TB diagnostics, epidemiology, and control strategies. His work evaluating the Xpert MTB/RIF assay influenced its global implementation, leading to earlier and more accurate TB diagnoses, particularly in high-burden settings. A landmark randomized controlled trial led by his team demonstrated the assay’s clinical impact and feasibility at the point-of-care, contributing to World Health Organization (WHO) policy recommendations. He has also led and participated in several systematic review and meta-analyses for policy formulation.
Beyond diagnostics, his research has deepened understanding of TB transmission dynamics, including how cough aerosols contribute to TB spread, leading to novel insights into transmission risk factors and public health interventions. His work on the TB microbiome explores host-pathogen interactions, with implications for treatment responses and the development of new therapeutic approaches.
Prof. Theron has received numerous prestigious awards, including an NRF P-rating, which recognizes young researchers with the potential to become international leaders in their fields. He has authored over 150 peer-reviewed publications in high-impact journals, with his research frequently cited in global TB guidelines and policy documents.
Prof. Theron has supervised and mentored numerous postgraduate students and postdoctoral fellows, many of whom have gone on to establish successful academic and clinical research careers. His research group provides a dynamic and multidisciplinary training environment, equipping early-career scientists with expertise in molecular biology, epidemiology, and biostatistics, coupled with project and grant management skills.
He actively contributes to international TB training initiatives and collaborations, ensuring knowledge transfer and capacity building in resource-limited settings. His leadership in multi-country research consortia fosters cross-disciplinary learning, encouraging young researchers to engage in translational research that bridges laboratory findings with real-world clinical applications.
In summary, Prof. Theron’s contributions to TB research extend beyond academic achievements to tangible public health impact. His work has shaped TB diagnostic policies, enhanced understanding of disease transmission, and fostered critical training opportunities for emerging researchers. Through his continued leadership and collaboration, he remains at the forefront of efforts to improve TB control and patient outcomes globally.
