Mario Cascio has been living with HIV for over 40 years. He is a founding member of NPS Italia APS, the first Italian network of people with HIV and is former chair and currently the Quality of Life Programme Chair of the European AIDS Treatment Group (EATG). He is also a steering group member of the HIV Outcomes Initiative, focusing on improving the long-term management and HRQoL of people with HIV. And recently he is a founding member of iCOPe HIV, the International Coalition of Older People living with HIV, giving voice and advocating for the emerging and often neglected needs of ageing and older people living with HIV.