International Workshop on Clinical Pharmacology of Tuberculosis Drugs 2021
Meeting category
Date(s)
11 Nov 2021 - 12 Nov 2021
Meeting type
Virtual Meeting
Organizer

International Workshop on Clinical Pharmacology of Tuberculosis Drugs 2021

Related Enduring Materials

Enduring Materials
Day 1: Thursday, 11 November 2021 - 15:00
15:00 PM CET - 9:00 AM ET
Opening of the Workshop
Rob Aarnoutse, PharmD, PhD
Radboud University Medical Center, Netherlands
Charles Peloquin, PharmD
University of Florida, United States
Session 1: Pharmacokinetics & Pharmacodynamics of Established TB drugs -
Chairs
Helen McIlleron, MBChB, PhD
University of Cape Town, South Africa
Eric Nuermberger, MD
Johns Hopkins University, United States
15:05 PM CET - 9:05 AM EST
Lessons Learned for Future TB Drug Development: A Review of Rifapentine
Kelly Elise Dooley, M.D., Ph.D., M.P.H.
Johns Hopkins University, United States
15:25 PM CET - 9:25 AM EST
Abstract-Driven Presentations
Pharmacokinetics of Rifampicin in Plasma, Cerebrospinal Fluid, and Brain Extracellular Fluid in South African Children with Tuberculous Meningitis: Application of Brain Microdialysis
1# Ms. Noha Abdelgawad
Optimized loading period strategies for bedaquiline at the restart of drug-resistant tuberculosis treatment
#2 Mr. Simon Koele
Population pharmacokinetics of cycloserine, administered as terizidone, in South African children treated for rifampicin-resistant tuberculosis.
3# Dr. Louvina Elizabeth Van Der Laan
Session 2 : Pharmacokinetics & Pharmacodynamics of New and Repurposed TB drugs - 16:40
16:40 PM CET - 10:40 AM EST
Host Directed Therapy (Including the Role of Immunity in Understanding Conventional Approaches)
Robert S Wallis, MD, FIDSA, FRCPE
Aurum Institute, United States
Pravastatin pharmacokinetics when administered simultaneously with first-line tuberculosis treatment: surprising interim results from the StAT-TB trial
#4 Dr. Elisa Ignatius
Incidence and determinants of linezolid toxicity in patients with drug-resistant tuberculosis in a high HIV prevalence setting: a prospective cohort study
#5 Dr. Sean Wasserman
A Population Pharmacokinetic Model of Linezolid enabling Model-Informed Precision Dosing in Resistant Tuberculosis Patients
#6 Mx. Laurynas Mockeliunas
18:00 PM CET - 12:00 PM EST
Guided Posted Tour I Day 1
A model-based analysis of bedaquiline-related QTcF prolongation in the PROBeX study
#13 Mr. Stijn Van Beek
Pentamidine shows promising activity against M. tuberculosis and M. avium complex but not M. abscessus
#14 Mr. Jelmer Raaijmakers
Cerebrospinal Fluid Concentrations of New and Repurposed Drugs among Patients with Tuberculosis Meningitis
#15 Dr. Russell Kempker
PK/PD-guided high-dose second-line therapy of patients with advanced level drug-resistant TB
#16 Mr. Niklas Köhler
Plasma bedaquiline levels in Indian MDR-TB patients
#17 Dr. Prerna Arora
Session 3 : Population Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Modeling of TB Drugs - 15:05
15:05 PM CET -9:05 AM EST
Beyond burden: Physiologic readouts give new perspective for TB regimen development.
Nicholas Walter, MD, PhD
CU Denver, United States
15:25 PM CET - 9:25 AM EST
Abstract-Driven Presentations
A model-guided weight-banded dosing strategy for once daily delamanid in children
7# Dr. Maria C. Kjellsson
Exposure-response relationship for bedaquiline, delamanid, and their metabolites with QTcF and model-based predictions of QTcF with once-daily dosing
8# Mrs. Lénaïg Tanneau
Concentration-QTcF modelling and drug-drug interaction of Bedaquiline, Pretomanid and Clofazimine in TB patients.
9# Dr. Mahmoud Tareq Abdelwahab
Session 4 : TB Drug Development and Optimization: Approaches and Tools - 16:40
16:40 PM CET - 10:40 AM EST
Long-Acting Injectables for TB
William Spreen, PhD
ViiV Healthcare · Research & Development Doctor of Pharmacy
Susan Swindells, MBBS
University of Nebraska Medical Center, United States
17:10 PM CET -11:10 AM EST
Abstract-Driven Presentations
Evaluating the effect of clofazimine against Mycobacterium tuberculosis when given alone or in combination with pretomanid, bedaquiline or linezolid
#10 Dr. Sarah Kim
Simulation by oral dosing of rifapentine/rifabutin exposures for long-acting formulations in a mouse model of tuberculosis preventive therapy
11# Eric Nuermberger
Investigating the treatment shorting potential of sutezolid-containing regimens in a murine model with confirmed drug exposures
12# Dr. Lindsey Te Brake
16:10 PM CET -12:10 EST
Guided Poster Tour I Day 2
Population Pharmacokinetic Modeling of Pretomanid Dispersible-Tablet Formulation in Healthy Volunteers
#18 Ms. Yuanxi Zou
Operational Challenges with Centralising PK Bioanalysis in a Multicentre Multinational Randomised Controlled Trial
#19 Dr. Christopher Cousins
Pharmacokinetics of linezolid in Indian patients with multidrug-resistant tuberculosis
#20 Dr. Juan Eduardo Reséndiz-Galván
Rifampin Urine Colorimetry for Evaluation of Tuberculosis Pharmacokinetics
#21 Ms. Prakruti Rao
Overview
Image
Website Image TBPK 2021
Welcome

After an absence of one year due to the COVID-19 pandemic, we are pleased to announce that the 13th edition of the International Workshop on Clinical Pharmacology of Tuberculosis Drugs took place from 11-12 November 2021, as a virtual meeting.

This abstract-driven workshop has been the leading annual meeting in the tuberculosis (TB) pharmacology field since 2008. The aim of the meeting is to contribute to the optimization of TB treatment by providing an independent platform for presentation and discussion of the latest scientific developments in the TB pharmacology field.

The target audience of this workshop are preclinical and clinical pharmacology researchers from academia and industry; medical doctors, pharmacists and pharmacologists involved in clinical management of TB patients; PhD students; and representatives from regulatory or non-governmental organizations active in the TB-field.

The program consisted of state-of-the-art lectures by selected invited experts, combined with oral and poster abstract presentations. The workshop was informal in setting and highly interactive.

Workshop Chair 2021

General Information 

COVID-19 Update
In light of the ongoing COVID-19 situation, the Organizing Committee of the International Workshop on Clinical Pharmacology of Tuberculosis Drugs 2021 meeting has decided to hold this year's program as a virtual meeting from 11-12 November. The program will be delivered safely and conveniently for all participants and conducted through our interactive online platform.

We are available to answer any questions or concerns that you may have about your participation at the International Workshop on Clinical Pharmacology of Tuberculosis Drugs 2021. For more information, please contact mariam.hafsa@amededu.com

To stay updated on developments about this meeting, make sure that you are signed up for our newsletter.
Who Should Attend?
- Physicians involved in Tuberculosis care and prevention

- Pharmacologists, nurses, and other healthcare professionals involved in Tuberculosis care and prevention

- Healthcare administrators, policymakers, and (non)government representatives
Learning Objectives
After participating in International Workshop on Clinical Pharmacology of Tuberculosis Drugs 2021, participants will be able to:

- Describe pharmacokinetics and pharmacodynamics of new, repurposed, and established TB drugs;
- Outline advances made to TB drug development and optimization; and
- Define pharmacokinetics and pharmacokinetic-pharmacodynamic modeling of TB Drugs.
Meeting Objectives
This workshop aims to:

- Gather experts involved in the clinical pharmacology of TB drugs from different disciplines;
- Provide a platform for presentation and discussion of the latest scientific developments in the field; and
- Map current studies and results related to available and new TB drugs.


Practical Information 

We trust that the following information (in alphabetical order) will assist you in organizing your participation in the International Workshop on Clinical Pharmacology of Tuberculosis Drugs 2021.

Certificate of Attendance
A certificate of attendance will be sent to participants that have successfully completed the program and post-meeting survey.
Disclaimer
This meeting is intended for educational purposes only and aims to offer participants the opportunity to share information. The Organizing Secretariat of meeting, Academic Medical Education, cannot accept any liability for the scientific content of the sessions or for any claims which may result from the use of information or publications from the meeting. Academic Medical Education disclaims all liability for injuries or losses of whatever nature incurred by individuals attending this meeting.
Language
The official language of this meeting is English. Translation is not provided.
Liability and Insurance
By registering for the meeting, participants agree that the organizers do not accept responsibility for medical-, travel- or personal insurance. Participants are advised to take out their own insurance policies.
Committees
Organizing Committee

The members of the Organizing Committee (OC) are a group of carefully selected experts and inspirational leaders in their respective fields. They meet frequently to discuss the scientific program of the workshop, identify interesting topics and candidate speakers, and review all submitted abstracts. 

Scientific Committee

The members of Scientific Committee are hand-picked by the Organizing Committee (OC) and the conference secretariat based on their significant contributions and commitment to the field. They assist the OC by providing them with suggestions for speakers and topics. In addition, members of the Scientific Committee participate in reviewing submitted abstracts, and play an active role during the workshop as moderators and/or chairs of sessions.

  • Jan-Willem Alffenaar, PharmD, PhD - The University of Sydney School of Pharmacy, Australia
  • Deron Burton, MD, JD, MPH - CDC/OID/NCHHSTP, USA
  • Dakshina Chilukuri, PhD - FDA, USA
  • Veronique Dartois, PhD - Rutgers, The State University of New Jersey, USA
  • Paolo Denti , PhD - University of Cape Town, South Africa
  • Kelly Dooley, MD, PhD - Johns Hopkins University, USA
  • Tawanda Gumbo, MD - Southwestern Medical Center, USA
  • Richard Hafner, MD - NIH, USA
  • Scott Heysell , MD, MPH - University of Virginia, USA
  • Anneke Hesseling, MD - South Africa
  • Russell Kempker , MD, MSc - Emory University School of Medicine, USA
  • Steven Kern, PhD - Bill & Melinda Gates Foundation, USA
  • Christian Lienhardt, MD, PhD - WHO, Stop TB Department, France
  • Khisi Mdluli, PhD, Bill & Melinda Gates Medical Research Institute, USA
  • Rovina Ruslami , MD, PhD - Padjadjaran University, Indonesia
  • Ulrika Simonsson, PharmD, PhD - Uppsala University, Sweden
  • Susan Swindells, MBBS - University of Nebraska Medical Center, USA
  • Bob Wallis, PhD - The Aurum Institute, South Africa
Support
Principal Supporter
Contributor

Support Our Initiative
Financial backing helps us deliver an impactful meeting experience for the benefit of healthcare professionals, researchers, and community representatives involved in the International Workshop on Clinical Pharmacology of Tuberculosis Drugs 2021.
 
This collaboration plays a vital role in both the organizational as well as scientific success of the program.
 
To show your commitment to the cause and get in touch with us for a tailored support package, please contact Ms. Victoria Andreano at victoria.andreano@amededu.com.
 
Benefits of Support 
By supporting this program, we can offer the following advantages for your company.* Please contact us for the most recent support level benefits for this program.

  • Symposium opportunities
  • Non-commercial interviews with company representatives
  • Verbal acknowledgment during the program 
  • Discounted and complimentary registrations for your representatives
  • Company acknowledgment on digital meeting materials including but not limited to newsletters, flyers, the streaming platform, and our website
  • Company acknowledgment on printed meeting materials including but not limited to banners and the program book
  • Digital and printed advertising opportunities 
  • Social media shout-outs
  • Logo on the conference bag 

 
*Subject to the support level