TBPK
Meeting category
Date(s)
15 Oct 2017
Location
Atlanta, United States
Organizer

International Workshop on Clinical Pharmacology of Tuberculosis Drugs 2017

Related Enduring Materials

Enduring Materials

Sunday, 15 October 2017

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Workshop Opening
Rob Aarnoutse
Rob Aarnoutse, PharmD, PhD
Radboud University Medical Center, The Netherlands
Session 1: Pharmacokinetics & Pharmacodynamics of New & Repurposed TB Drugs -
Chairs
Rob Aarnoutse
Rob Aarnoutse, PharmD, PhD
Radboud University Medical Center, The Netherlands
Rovina Ruslami
Rovina Ruslami, MD, PhD
Universitas Padjadjaran, Indonesia
Searching for a Universal Regimen for Tuberculosis Treatment with a Shorter Duration of Therapy
Khisi Mdluli
Khisi Mdluli, PhD
TB Alliance, USA
Abstract presentations
Exposure-Response Analysis of Lee 1810, a Lead Spectinamide Antibiotic in Mycobacterium tuberculosis Infected Mice
Santosh Wagh
University of Tennessee Health Science Center, USA
Improved efficacy of a cofactor-independent InhA inhibitor revealed by the C3HeB/ FeJ mouse model
Gregory Robertson
Colorado State University, USA
Pharmacokinetic modeling and simulation of pretomanid in pulmonary tuberculosis patients
Michael Lyons
Colorado State University, USA
High dose rifampicin for the treatment of TB meningitis: a dose finding study
Rob Aarnoutse, PharmD, PhD
Radboud University Medical Center, Netherlands
Session 2: Pharmacokinetics & pharmacodynamics of approved TB drugs -
Chairs
Geraint Davie
Geraint Davie, MD
University of Liverpool, UK
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Paolo Denti, PhD
University of Cape Town, South Africa
A Cardiac Risk Algorithm to Predict the Probability of Drug-Induced Torsades de Pointes with Novel Anti-TB Agents
Alexander Berg
Alexander Berg, PharmD, PhD, FCP
Critical Path Institute; Tucson, USA
Abstract presentations
Optimizing the Dose of Levofloxacin: Pharmacokinetic Results from the Opti-Q Study
Charles Peloquin
University of Florida, USA
Ototoxicity is associated with exposure to kanamycin and capreomycin in the treatment of multidrug-resistant tuberculosis
Mohammed Aslshaer
University of Florida, USA
Pyrazinamide sterilizes necrotic lesions in tuberculosis infected lungs
Veronique Dartois
Rutgers University, USA
Moxifloxacin as the fluoroquinolone of choice to treat TB?
Jansy Sarathy
Rutgers University, USA
Session 3: Population Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Modelling -
Chairs
Khisi Mdluli
Khisi Mdlul, PhD
TB Alliance, USA
Dakshina Chilukuri
Dakshina Chilukuri, PhD
FDA, USA
Benefits of data collaboration – personalized tailoring regimens
Rada Savic
Rada Savic, PharmD, PhD
University of California, USA
Abstract presentations
Pharmacokinetics of rifampicin in African children - Evaluation of the new WHO dosing guidelines
Paolo Denti
University of Cape Town, South Africa
Prediction of increase in time-to-positivity after higher doses of rifampicin based on pharmacokinetic-pharmacodynamic modelling
Robin Svensson
Uppsala University, Sweden
Relating rifampicin exposure to treatment response in patients with pulmonary tuberculosis – potential for treatment shortening with higher doses
Elin Svensson
Radboud University Medical Center, Netherlands
Population Pharmacokinetic Modeling of Clofazimine in Adult Tuberculosis Patients: Implications for Dosing
Stella Belonwu
University of California, USA
Session 4: Drug development and optimization: approaches and tools -
Chairs
Charles Peloquin, PharmD
University of Florida, United States
Eric Nuermberger, MD
Johns Hopkins University, United States
Translation of pre-clinical models to clinical outcomes
Tawanda Gumbo
Tawanda Gumbo, MD
Baylor Institute for Immunology Research, USA
Abstract presentations
Quantitative Analysis of MGIT Time to Positivity Using a Two-Part Longitudinal Model in Patients with Pulmonary Tuberculosis: A Meta-Analysis of 11 Clinical Studies Including 30 Unique Regimens
JF Marier
Certara, Canada
Influence of Bacterial Growth Rate on Dose Optimization of Linezolid for Treatment of Tuberculosis
Kristina Bigelow
Johns Hopkins University, USA
A pharmacokinetic/pharmacodynamic drug-drug interaction study of rifampicin and metformin in type II diabetic tuberculosis patients
Lindsey te Brake
Radboud University Medical Center, Netherlands
Personalized tuberculosis treatment through Bayesian dosing of rifampicin
Stijn van Beek
Radboud University Medical Center, Netherlands
Overview
Welcome

We are pleased to announce the 10th edition of the International Workshop on Pharmacology of Tuberculosis Drugs which is scheduled for 15 October 2017 in Atlanta, USA.

The treatment of Tuberculosis is increasingly becoming a challenge worldwide. All around the world experts in the field are involved in intensive research to be able to cope with the various concerns with regard to treatment.

The aim of this abstract-driven workshop is to make a significant contribution to the optimization of TB treatment, by bringing experts together and having them present and discuss the latest important scientific findings in the TB clinical pharmacology field. Additionally, scientific, regulatory or strategy issues that are highly relevant to the optimization of TB treatment will be exchanged and discussed.

The format of the meeting will be a one-day workshop consisting of invited lectures, abstract presentations and roundtable discussions. Much time will be allocated to questions, answers and discussion in order to set up an intimate interactive workshop.

Topics that will be addressed include pharmacokinetics and pharmacodynamics of new TB drugs, Pharmacokinetics and pharmacodynamics of approved TB drugs, Pharmacokinetic – pharmacodynamic modeling, Drug-drug and drug-disease internactions, New TB drug development tools, new developments in pediatric TB, interactions between TB and HIV drugs, and treatment of MDR- and XDR-TB.

The target audience of this meeting consists of clinical pharmacologists, pharmacists, industry researchers, ID doctors, pediatricians, microbiologists, government representatives and other experts with an interest in clinical pharmacology.

General Information

Meeting Objectives
- To gather experts involved in the pharmacology of TB drugs from different disciplines in an interactive workshop setting
- To provide a platform for presentation and discussion of the latest scientific developments in the field.
- To map all current studies and results related to available and new TB drugs
- To help translate new in vitro and in vivo pharmacological data into new drug treatment combinations for TB
Unique Features
Our workshop involves a strong community of clinical pharmacologists and other healthcare professionals working in the TB-field. Also, the workshop provides an independent scientific platform to discuss controversial topics and views.

Practical Information

Disclaimer
This workshop is intended for educational purposes only and aims to offer participants the opportunity to share information. The organizing secretariat of this workshop, Expert Medical Events, cannot accept any liability for the scientific content of the sessions or for any claims which may result from the use of information or publications from this workshop. Expert Medical Events disclaims all liability for injuries or losses of whatever nature incurred by individuals attending the workshop.
Liability and Insurance
By registering for the conference participants agree that the organizers do not accept responsibility for medical, travel, or personal insurance. Participants are advised to take out their own insurance policies.
Photograph, Audio and Video Recording
Photographs as well as audio and video recordings are not permitted during official meeting sessions. Only the official medical writer appointed by the organization may make recordings. All presentations will be posted on the workshop website as soon as possible following the meeting, provided the speaker has given us permission to use their presentation online.
Committees
Organizing Committee

The members of the Organizing Committee (OC) discuss, on a frequent basis, the scientific program of the workshop, identify interesting topics and candidate speakers and review all submitted abstracts.

Khisi Mdluli, PhD
Khisi Mdluli, PhD
Bill & Melinda Gates Medical Research Institute
Scientific Committee

The members of Scientific Committee assist the OC by providing them with suggestions for speakers and topics. In addition, members of the Scientific Committee actively participate in reviewing submitted abstracts.

  • Jan-Willem Alffenaar, PhD, PharmD UMCG, The Netherlands
  • Deron Burton CDC, USA
  • Dakshina Chilukuri, PhD FDA, USA
  • Véronique Dartois, PhD Rutgers, The State University of New Jersey, Newark, USA
  • Paolo Denti, PhD University of Cape Town, South Africa
  • Kelly Dooley, MD, PhD Johns Hopkins University, USA
  • Tawanda Gumbo, MD Baylor Institute for Immunology Research, USA
  • Richard Hafner, MD National Institutes of Health, USA
  • Scott Heysell, MD, MPH University of Virginia, USA
  • Anneke Hesseling, MD Desmond Tutu Tuberculosis Centre, South Africa
  • Russell Kempker, MD, MSc Emory University School of Medicine, USA
  • Steven Kern, PhD Bill & Melinda Gates Foundation, USA
  • Christian Lienhardt, MD, PhD WHO – Stop TB Department, Switzerland
  • Rovina Ruslami, MD, PhD Padjadjaran University, Indonesia
  • Ulrika Simonsson, PharmD, PhD Uppsala University, Sweden
  • Susan Swindells, MBBS University of Nebraska Medical Center, USA
  • Andrew Vernon, MD CDC, TBTC, USA
  • Robert Wallis, MD, FIDSA The Aurum Institute, South Africa
Support