HBVCure New
Meeting category
Date(s)
7 Nov 2018
Location
Toronto, Canada
Meeting type
Live Meeting
Organizer

International Workshop on HBV Cure 2018

Related Enduring Materials

Enduring Materials
Program

The 5th edition of the International HBV Cure Workshop featured the world's most prominent and distinguished speakers that discussed the most current and trending issues in the field.Ā 

Ā Wednesday, 7 November 2018

- 08:00
08:00 EDT
Welcome
Session 1: Modulating approved therapies to achieve HBV Cure - 08:05
08:05 EDT
What is the cure rate with current therapies?
Harry Janssen, MD, PhD
Erasmus MC, University Hospital Rotterdam, the Netherlands / Toronto Centre for Liver Disease, Canada
08:20 EDT
Stopping Nucleos(t)ide Analogues: When is it beneficial, when is it dangerous?
Thomas Berg, MD
University of Leipzig, Germany
08:35 EDT
Immune reconstitution with current available antiviral therapies: a baseline to gauge new immunotherapies.
Andre Boonstra
Andre Boonstra
Erasmus Medical Center, the Netherlands
08:50 EDT
Discussion
Session 2: New Endpoints and Biomarkers - 10:00
10:00 EDT
What are the pros and cons of HBsAg loss as the endpoint for treatment?
Jordan Feld, MD, MPH
Toronto Centre for Liver Disease, Canada
10:15 EDT
Can we measure (activity of) cccDNA in the blood?
Massimo Levrero, MD
Hopital de la Croix-Rousse, France
10:30 EDT
Will HBsAg depletion restore HBV specific immunity?
Adam Gehring, PhD
Toronto Centre for Liver Disease, Canada
10:45 EDT
Discussion
Session 3: Update on Immune Targets for HBV Therapy - 11:35
11:35 EDT
Rationale for modulating innate immunity: TLR, RIG- and others
Mala Maini, MD, PhD
University College London, United Kingdom
11:50 EDT
Antiviral effect of the RIG-I agonist, Inarigavir
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Nezam Afdahl
University of Freiburg, Germany
12:00 EDT
Activating Toll-like receptor (TLR)-8 with GS-9688 for HBV therapy
Simon Fletcher
Simon Fletcher
Gilead Sciences, Foster City, USA
12:10 EDT
Combination treatment of a TLR7 agonist RO7020531 and a core protein allosteric modulator RO7049389 achieved sustainable viral load suppression and HBsAg loss in an AAV-HBV mouse model
Lu Gao
Lu Gao
Roche Innovation Center Shanghai, Shanghai, China
12:20 EDT
Innate activation with Inactivated parapox viruses for HBV therapy - AIC649
Paulsen
Daniela Paulsen
Springbank Pharmaceuticals, Inc.
13:30 EDT
Rationale for Modulating Adaptive Immunity: Therapeutic Vaccination, Checkpoint Inhibitor and others
Robert Thimme
Robert Thimme
University of Freiburg, Freiburg, Germany
13:45 EDT
Anti-HBV potential of PD-1/PD-L1 blockade in chronic HBV infection
Daniel Verdon
Daniel Verdon
University of Auckland, Auckland, New Zealand
14:00 EDT
Discussion
Session 4: Update on Virologic Targets for HBV Therapy - 15:15
15:15 EDT
Rationale for different Virological Targets in HBV
Stephen Locarnini, BSc(Hons), PhD, MBBS, FRC(Path)
Victorian Infectious Diseases Reference Laboratory
15:30 EDT
Clinical progress of the entry inhibitor Myrcludex B
Stephan Urban
Stephan Urban
University of Heidelberg, Heidelberg, Germany
15:45 EDT
Establishing functional control of HBV and HDV infection with REP 2139-based combination therapy
Andrew Vaillant
Andrew Vaillant
Replicor, Montreal, Canada
15:55 EDT
Clinical update on reducing HBV virus and antigen production using RNAi
Bruce Given
Bruce Given
Arrowhead, Pasadina, USA
16:05 EDT
Clinical update, antiviral effect and mode of action of capsid assembly modulators
Jeysen Yogaratnam
Jeysen Yogaratnam
Janssen Biopharma, South San Francisco, USA
16:15 EDT
Targeting HBV Core Protein to Clear Infection and Achieve Higher Cure Rates
Richard Colonno
Rich Colonno
Assembly Bioscience, San Francisco, USA
16:25 EDT
Roundtable
17:00 EDT
Closure of the Workshop
Overview
Welcome

We are pleased to look back on a very succesful 5th edition of theĀ International HBV Cure Workshop, held in Toronto, ON, Canada on Wednesday 7 November 2018.

More than 100 delegates attended the workshop and the Organizing committee and organizers would like to thank the speakers, chairs and all participants for their contribution to this meeting!Ā In particular we would like to thank our workshop sponsors. Without their financial contribution this workshop would not have been made possible.

The slides and the webcasts of the presentations given during the meeting (provided the speaker's consent was received) are soon available at http://www.infectiousdiseasesonline.com.

We look forward to seeing you again at the next International HBV Cure Workshop.Ā 

The Organizing committee

Background

More than 250 million people are chronically infected with hepatitis B (HBV) around the globe. The purpose of the program is to inform the participants about the developments in the possibilities to find a cure for HBV. The meeting will be highly interactive with input from experts out of the arena of basic, translational and clinical HBV research.

The field of HBV treatment is undergoing major changes and is on the verge of a paradigm shift. The many new treatment options that are becoming available are providing great hopes for decreasing the burden of the disease, simplifying treatment and ultimately curing and eradicating HBV infection.

In order to optimize curative treatment for HBV, outstanding speakers from around the globe will share the newest therapeutic options for viral hepatitis and experts will discuss the path forward to cure this deadly disease, leading to liver cirrhosis and liver cancer. Questions on which end points to use in therapeutic trials and how to combine different agents targeting the virus and/or immune system will be extensively discussed.

This workshop also brings together global inter-disciplinary experts to provide a framework for how academia and industry should could collaborate to achieve the goal of curing hepatitis B.

Committees
Organizing Committee

The members of the Organizing Committee (OC) discuss, on a frequent basis, the scientific program of the workshop, identify interesting topics and candidate speakers.

Organizing Committee
Harry Janssen 2019
Harry Janssen, MD, PhD
Erasmus MC, University Hospital Rotterdam, the Netherlands / Toronto Centre for Liver Disease, Canada
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