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Meeting category
Date(s)
21 Nov 2019 - 22 Nov 2019
Location
Amsterdam, Netherlands
Organizer

International Workshop on Clinical Pharmacology of Anticancer Drugs (ICPAD) 2019

Related Enduring Materials

Enduring Materials

Please note: no videos are available for the ICPAD presentations

Program

Day 1 - Thursday, 21 November 2019

Session 1: Redesigning studies and endpoints with immuno oncology -
Chairs
Howard Gurney, MBBS, FRACP
Westmead Hospital, Australia
Nielka van Erp, PharmD, PhD
Radboud University Medical Center, Netherlands
Changes and Challenges in Early Phase Trial Endpoints
Ruth Plummer, MD
Newcastle University, United Kingdom
New Designs for Early Clinical Trials of IO Drugs
Emiliano Calvo, MD, PhD
START Madrid, Early Clinical Oncology Drug Development Program
Abstract-driven presentations -
Prediction of Capecitabine induced Severe Toxicity using Machine Learning Techniques
Maël Steunou
France
Long Term Pemetrexed-based Cancer Treatment Leads to Nephrotoxicity
Nikki de Rouw
Netherlands
Session 2: Imaging, genetics and environment -
Chairs
Nielka van Erp, PharmD, PhD
Radboud University Medical Center, Netherlands
Stijn Koolen, PharmD, PhD
Erasmus MC Cancer Institute, Netherlands
The Use of Radiolabeled and Fluorescent Monoclonal Antibodies for Molecular Imaging in Oncology
Annelies Jorritsma-Smit, PharmD, PhD
University Medical Center Groningen, Netherlands
The Long and Winding Road of the Clinical Introduction of a Biomarker
Jack Schalken, PhD
Radboud University Medical Centre, Netherlands
Abstract-driven presentations -
Epigenetic Regulation of OCTN1-mediated Cytarabine Transport in Acute Myeloid Leukemia
Jason Anderson
USA
Comprehensive Pan-Cancer Analysis of Somatic Mutations in Drug Transporters to Reveal Acquired and Intrinsic Drug Resistance in 3149 Metastatic Cancer Patients
Wesley van de Geer
Netherlands
Session 3: PK/PD studies and new strategies -
Chairs
Maria-Jesus Garrido, PhD
University of Navarra, Spain
Lena Friberg, PhD
Uppsala University, Sweden
How System Pharmacology Can Facilitate Clinical Drug Development in Oncology
Impact of Immortal Time and Selection Bias on Exposure-response Modelling
Mats Karlsson, PhD, FCP, FISoP
Uppsala University, Sweden
Clinical Pharmacology Strategy for Development and Labelling of New Medicine in the Era of Targeted Therapy and Accelerated Approvals in Oncology
Alienor Berges, PharmD
Quantitative Clinical Pharmacology, AstraZeneca Cambridge, United Kingdom
Stein Schalkwijk, PharmD, PhD
Quantitative Clinical Pharmacology, AstraZeneca Cambridge, UK
Abstract-driven presentations -
Quantitative Modelling of Inter-lesion and Inter-organ Variability of Tumor Size
Sreenath Krishnan
Sweden
Population Pharmacodynamics Modelling of Circulating Lymphocyte Count Over Time in Chronic Lymphocytic Leukemia Patients Under Ibrutinib Treatment
Fanny Gallais
France

Day 2 - Friday, 22 November 2019

Session 4: Optimal study design & biomarker selection and validation -
Chairs
Michelle Rudek, PharmD, PhD
Johns Hopkins University, United States
Etienne Chatelut, PharmD, PhD
Institut Universitaire du Cancer Toulouse - Oncopole, France
Optimal Study Design of Oncology Trials
Patricia LoRusso, PhD
Yale Cancer Center, United States
Challenges in the Development of Immunotherapy
Abstract-driven presentations -
Pharmacokinetics and Safety of Pazopanib in Frail Elderly Patients
Félicien Le Louedec
France
Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Adrenocortical Carcinoma Patients: Towards Individualized Dosing
Anyue Yin
Netherlands
Session 5: Drug-Drug / Drug-Food / Drug-environmental interactions -
Chairs
Ron Mathijssen, MD, PhD
Department of Medical Oncology, Erasmus MC, Netherlands
Howard Gurney, MBBS, FRACP
Westmead Hospital, Australia
Drug - Food Interaction: An Unrealized Potential
Nielka van Erp, PharmD, PhD
Radboud University Medical Center, Netherlands
Challenges in Treating Geriatric Patients With Cancer
Etienne Chatelut, PharmD, PhD
Institut Universitaire du Cancer Toulouse - Oncopole, France
Abstract-driven presentations -
Modulation of CYP3A activity to Increase the Oral Bioavailability of Ibrutinib
Eric Eisenmann
USA
Effects of Dietary Restriction in Cancer Patients Receiving Irinotecan
Ruben van Eerden
Netherlands
Session 6: Dose individualization approaches -
Chair
Michelle Rudek, PharmD, PhD
Johns Hopkins University, United States
Etienne Chatelut, PharmD, PhD
Institut Universitaire du Cancer Toulouse - Oncopole, France
Dose Individualization Potential for Oral Targeted Oncolytics
Neeltje Steeghs, MD, PhD
Netherland Cancer Institute, Netherlands
Dose Individualization Potential for Checkpoint Inhibitors
Stijn Koolen, PharmD, PhD
Erasmus MC Cancer Institute, Netherlands
Abstract-driven presentation -
Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib
Koen Hussaarts
Netherlands
Correlation Between Sunitinib Exposure and Toxicity in a Real-life Patient Cohort
Kim Westerdijk
Netherlands
Overview
Welcome

We are pleased to look back on a very successful the 4th International Workshop on Clinical Pharmacology of Anticancer Drugs (ICPAD), held on the 21st and 22nd November 2019 in Amsterdam, the Netherlands. 

The Organizing Committee and organizers would like to thank the speakers, chairs and all participants for their contribution to this meeting! Special thanks to the workshop sponsors: Daiichi Sankyo, Inc.Boehringer IngelheimPfizer Oncology, and Celgene. Without their contributions this workshop would not have been possible.

The slides of the presentations given during the meeting, provided the speaker's consent was received, are available here.

We look forward to seeing you again at the next International Workshop on Clinical Pharmacology of Anticancer Drugs (ICPAD). 

The Organizing Committee

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ICPAD 2019 group photo